Crossword clue
“Most significant”
This clue appeared as Across in the Newsday Crossword on Sunday, December 28, 2025. The answer has 4 letters.
Answer · 4 lettersSeen 2 times
MAINLetters4
Starts withM
Ends withN
Vowels2
Where this clue has appeared
About this clue
The clue “Most significant” ran in the Newsday Crossword on December 28, 2025 as Across. Its answer is a 4-letter word that starts with M and ends with N.
See every answer from the puzzle on the Newsday Crossword page for December 28, 2025, or learn how clues like this work in our guide to crossword clue types.
More clues from this puzzle
FAQ
What is the answer to the “Most significant” clue?+
The answer is MAIN (4 letters), from the Newsday Crossword of December 28, 2025.
Where has this clue appeared?+
We have seen it 2 times in the Newsday Crossword, most recently on December 28, 2025.
How do I find other Newsday Crossword answers?+
Open the full list of answers for December 28, 2025, or browse every date on the Newsday Crossword hub.